Kisspeptin-10 is the ten-amino-acid C-terminal fragment of kisspeptin, the hypothalamic peptide that drives GnRH and therefore LH, FSH and testosterone release; the literature also calls it metastin 45-54 or kisspeptin 112-121. It is the form sold on the research market, in 5 mg and 10 mg vials on this site's calculator preset, and not the form the best-known human studies used: the 2005 and 2007 papers that made kisspeptin famous infused or injected the 54-amino-acid peptide. There is no approved product, no label and no labelled dose in any market. What exists is a set of academic physiology studies that gave kisspeptin-10 to healthy volunteers by intravenous bolus, intravenous infusion and, since 2026, subcutaneous infusion, every one of them dosed per kilogram of body weight.
This page reports those figures as the papers state them, converts them to a 70 kg adult, sets the figures that circulate on vendor pages beside them, and does the syringe arithmetic for both research vial sizes. It recommends nothing. The kisspeptin-10 calculator runs the same sums for any vial and volume, and the dosage hub indexes every compound this site covers.
What does not exist
- DailyMed: no record for kisspeptin or kisspeptin-10 on 2026-09-18.
- ClinicalTrials.gov: five registrations name kisspeptin-10, three completed physiology studies of 14, 15 and 30 people (NCT03771326, NCT03315325, NCT03286517) and two withdrawn before enrolling anyone (NCT04532801, NCT05456854).
- PubMed: 403 records mention kisspeptin-10, 110 tagged as human and nine as clinical trials; the human trials are the studies in the table below.
- No approved product anywhere, and therefore no label, no labelled dose and no labelled reconstitution.
What the human studies gave
| Study | Form | Route and dose as stated | People | What happened |
|---|---|---|---|---|
| George and colleagues, 2011 (PMID 21632807) | KP-10 | IV bolus 0.01 to 3.0 mcg/kg; IV infusion 4 mcg/kg/h for 22.5 h and 1.5 mcg/kg/h | healthy men, 6 per bolus, 4 per infusion | LH peaked at 1 mcg/kg; 3 mcg/kg gave less; infusions raised LH and testosterone |
| Jayasena and colleagues, 2011 (PMID 21976724) | KP-10 | IV bolus 0.3 to 10 nmol/kg; in women also SC bolus up to 32 nmol/kg and IV infusion up to 720 pmol/kg/min | healthy men and women, 4 to 5 per group | men responded from 0.3 nmol/kg; follicular-phase women did not respond to any route; preovulatory women responded to 10 nmol/kg |
| Chan and colleagues, 2011 (PMID 21470997) | KP-10 (kisspeptin 112-121) | single IV bolus; 0.24 nmol/kg per a 2026 paper from the Massachusetts General Hospital programme (PMID 41273106) | 13 healthy men | an immediate LH pulse and a reset of the GnRH pulse generator |
| George and colleagues, 2013 (PMID 23153270) | KP-10 | IV bolus 0.3 mcg/kg; IV infusion 4 mcg/kg/h for 11 h | 5 men with type 2 diabetes, 7 healthy | LH and testosterone rose in both groups |
| Yeung and colleagues, 2026 (PMID 42549827) | KP-10 | SC infusion 1.25 to 10 nmol/kg/h for 8 h; continuous 180 nmol/h for 5 days; 150 nmol/h for 8 h daily for 12 days; IV bolus 1 nmol/kg | 15 healthy men, 12 controls | dose-dependent rise; continuous infusion lost the gonadotropin response; daily infusion sustained it 12 days |
| Dhillo and colleagues, 2005 (PMID 16174713) | KP-54 | IV infusion 4 pmol/kg/min for 90 min | 6 men | LH, FSH and testosterone rose; half-life 27.6 min |
| Dhillo and colleagues, 2007 (PMID 17635940) | KP-54 | SC bolus 0.2 to 6.4 nmol/kg; 0.4 nmol/kg across the cycle | healthy women | dose-dependent LH rise, greatest in the preovulatory phase |
Every kisspeptin-10 figure is per kilogram, given in a research unit with serial sampling; none is a fixed amount, and only the 2026 pump study repeated beyond a day.
What a per-kilogram figure amounts to at 70 kg
The papers switch between mass and molar units. At a molecular weight of 1,302.4 (PubChem CID 25240297), 1 nmol/kg is 1.30 mcg/kg. The right-hand column is arithmetic for reading the papers, not an amount for anyone.
| Figure as stated | In mcg/kg | For a 70 kg adult |
|---|---|---|
| 0.24 nmol/kg IV bolus | 0.31 | 22 mcg |
| 0.3 nmol/kg IV bolus | 0.39 | 27 mcg |
| 1 mcg/kg IV bolus | 1 | 70 mcg |
| 3 mcg/kg IV bolus | 3 | 210 mcg |
| 10 nmol/kg IV bolus | 13.0 | 912 mcg |
| 32 nmol/kg SC bolus (women, no response) | 41.7 | 2.9 mg |
| 4 mcg/kg/h IV infusion | 4 per hour | 280 mcg per hour; 6.3 mg over 22.5 h |
| 1.25 to 10 nmol/kg/h SC infusion for 8 h | 1.6 to 13 per hour | 0.9 to 7.3 mg over 8 h |
| 150 nmol/h SC for 8 h daily | not per kg | 1.56 mg per day |
| 180 nmol/h SC continuous | not per kg | 5.6 mg per day |
The spread is the point: the intravenous boluses that produced the textbook LH pulses in men amount to 20 to 70 mcg, the subcutaneous infusions that sustained a response delivered 1.5 mg a day by pump, and a subcutaneous bolus forty times the bolus dose produced nothing in follicular-phase women. Route, sex and cycle phase changed the answer by orders of magnitude.
The figures that circulate
Vendor and forum pages read on 2026-09-18 cited 50 to 200 mcg subcutaneously once or twice daily, 100 to 500 mcg per injection, and 6 to 10 mcg/kg. None cites a study, and none corresponds to one: the studies' bolus figures are intravenous and smaller, the subcutaneous figures in men are pump infusions, and the only subcutaneous boluses in the literature were given to women and produced no response. Peptifact's kisspeptin page reads the same studies from the journalism side.
The arithmetic per vial
Concentration in mcg/mL is the vial amount divided by the water volume; micrograms per unit is that figure divided by 100, because a U-100 syringe holds 100 units in 1 mL and each small notch on a standard 1 mL insulin syringe is 1 unit (MedlinePlus, reviewed 2024-07-21). The columns are the 70 kg bolus conversions and the circulating figures, converted, not endorsed.
| Vial and water | mcg/mL | mcg per unit | 22 mcg | 70 mcg | 100 mcg | 250 mcg | 500 mcg |
|---|---|---|---|---|---|---|---|
| 5 mg in 1 mL | 5,000 | 50 | 0.4 units | 1.4 | 2 | 5 | 10 |
| 5 mg in 2 mL | 2,500 | 25 | 0.9 | 2.8 | 4 | 10 | 20 |
| 5 mg in 3 mL | 1,667 | 16.7 | 1.3 | 4.2 | 6 | 15 | 30 |
| 10 mg in 1 mL | 10,000 | 100 | 0.2 | 0.7 | 1 | 2.5 | 5 |
| 10 mg in 2 mL | 5,000 | 50 | 0.4 | 1.4 | 2 | 5 | 10 |
| 10 mg in 3 mL | 3,333 | 33.3 | 0.7 | 2.1 | 3 | 7.5 | 15 |
The trial-sized amounts are so small that no research-vial concentration reads them well: 22 mcg is under a unit in every row, and 70 mcg reaches 4 units only at the most dilute mix. It is also a reminder that those amounts went into a vein through a cannula, which is not a subcutaneous draw at all.
What the figures omit
The published figures carry a route, mostly intravenous; a setting, a research unit with blood drawn every ten minutes; a population of healthy volunteers or small groups of men with diabetes; a duration of hours, or 12 days in one study; and a hormone level as the endpoint, never a clinical outcome. The women's data carry a cycle phase without which the figure means nothing. No study gave men a single subcutaneous injection, ran longer than 12 days, measured safety beyond the session, or used a fixed microgram amount. The mechanism, the evidence file and the sourcing belong to Medibact's Kisspeptin-10 guide.
Status in the United States
FDA placed kisspeptin-10 in Category 2 of its section 503A bulk-substance list on 2023-09-29, the category for substances FDA says raise significant safety risks and may not be used in compounding under that section (list read 2026-09-18). When FDA sent seven peptides to its Pharmacy Compounding Advisory Committee for July 2026, kisspeptin-10 was not among them (Federal Register document 2026-07361, 2026-04-16), so its status did not move with theirs.
Sources and dates
Opened 2026-09-18: DailyMed (no record); ClinicalTrials.gov v2 API (five registrations, listed by number); PubMed, with the abstracts of PMIDs 21632807, 21976724, 21470997, 23153270, 42549827, 16174713, 17635940 and 41273106 read in full; PubChem CID 25240297 for the molecular weight; FDA's 503A category list dated 2023-09-29; Federal Register document 2026-07361; MedlinePlus, "Giving an insulin injection" (reviewed 2024-07-21); vendor and forum pages for the circulating figures. Vial sizes are the ones the calculator preset uses.
This page does not recommend a dose, a route, a frequency or a schedule, and it does not say what any figure means for a particular person. It reports what eight papers state, converts their per-kilogram figures so they can be read, and converts micrograms into syringe units, which is all it can honestly do.