5-Amino-1MQ is the odd entry in a library of peptides: a small molecule, not a chain of amino acids, sold in the same vials and measured on the same syringes. It inhibits nicotinamide N-methyltransferase, an enzyme in the NAD+ salvage pathway, and the interest in it comes from mouse experiments in obesity and aged muscle. This page reports what the published sources state about amounts, states the salt-form problem that moves every figure on the compound by a factor of about 1.8, and does the vial arithmetic. It recommends nothing, and the honest headline is that every published dose for this compound is a dose given to a mouse.
The 5-Amino-1MQ calculator runs the same sums for any vial and volume, the dosage hub indexes every compound covered here, and the all-compounds chart holds the one-line version of this page beside every other compound's.
What the sources state
| Source | What it states | Kind of source | Opened |
|---|---|---|---|
| Biochem Pharmacol, PMID 30753815 (2019) | 24-month-old mice given NNMT inhibitor at 5 and 10 mg/kg for one week, or 10 mg/kg for three weeks, after a chemically induced muscle injury; treated muscle showed nearly 2-fold greater fibre cross-sectional area and about 70% greater peak torque | Peer-reviewed animal study | 2026-09-19 |
| Biochem Pharmacol, PMID 29155147 (2018) | A potent NNMT inhibitor reduced body weight, white adipose mass, adipocyte size and plasma total cholesterol in diet-induced obese mice, without affecting food intake; no mg/kg figure in the abstract | Peer-reviewed animal study | 2026-09-19 |
| J Immunother Cancer, PMID 39067875 (2024) | 5-Amino-1-methylquinolinium iodide reduced tumour growth in bladder-cancer mouse models and enhanced the effect of an anti-PD-L1 antibody | Peer-reviewed animal study | 2026-09-19 |
| Sci Rep, PMID 35013352 (2022) | NNMT inhibitor plus a low-fat diet in diet-induced obese mice; the study is about the cecal microbiome, and the dose is not in the abstract | Peer-reviewed animal study | 2026-09-19 |
| ClinicalTrials.gov v2 API | No study with 5-Amino-1MQ as an intervention; no study for "NNMT inhibitor" | Trial registry | 2026-09-19 |
| DailyMed SPL search | Zero records for 5-amino-1mq | Regulator database | 2026-09-19 |
| PubChem CID 950107 and CID 66522933 | Cation C10H11N2+, 159.21 g/mol; iodide C10H11IN2, 286.11 g/mol | Chemical database | 2026-09-19 |
| FASEB J, PMID 17942826 (2008) | The body-surface-area method for translating animal doses, with the authors' statement that an animal dose should not be extrapolated to a human equivalent dose by simple conversion | Methods paper | 2026-09-19 |
Three indexed papers carry the compound's name, and the figures above are the whole published dose record. Nothing in it describes a person.
The salt-form correction, which is larger than the water volume
Every other compound on this site is weighed as a peptide and the milligram figure on the vial is the peptide. 5-Amino-1MQ is a quaternary ammonium cation and cannot exist on its own in a bottle; it is paired with a counter-ion, and the published work names the iodide. The two masses are 159.21 for the cation and 286.11 for the iodide, so the cation is 55.6% of the salt.
| If a 50 mg label means | Cation in the vial | Concentration in 2 mL | Cation per U-100 unit |
|---|---|---|---|
| 50 mg of cation (salt-corrected) | 50 mg | 25 mg/mL | 250 mcg |
| 50 mg of iodide salt | 27.8 mg | 13.9 mg/mL | 139 mcg |
The two rows differ by 80%. No arithmetic further down the page can recover that difference, and no choice of water volume affects it: it is set before the vial is opened, by what the label's milligram figure counts. The same ambiguity is why this site's coverage of N-acetyl Selank amidate insists that a certificate of analysis has to name the salt form. Where a certificate states the salt and the assay, the first row applies; where it does not, both rows are live and the figure carries an 80% uncertainty that is rarely mentioned.
Water per vial and the concentration it gives
The calculator's presets are the 50 mg and 100 mg vials, the sizes the compound is commonly supplied in. One U-100 unit is a hundredth of a millilitre (MedlinePlus, "Giving an insulin injection", reviewed 2024-07-21). These rows assume the label's milligrams are the cation; if the label describes the iodide, every figure in the right-hand column falls to 55.6% of what is shown.
| Vial | Water added | Concentration | Per U-100 unit |
|---|---|---|---|
| 50 mg | 1 mL | 50 mg/mL | 500 mcg |
| 50 mg | 2 mL | 25 mg/mL | 250 mcg |
| 50 mg | 3 mL | 16.7 mg/mL | 167 mcg |
| 100 mg | 1 mL | 100 mg/mL | 1,000 mcg |
| 100 mg | 2 mL | 50 mg/mL | 500 mcg |
| 100 mg | 3 mL | 33.3 mg/mL | 333 mcg |
These are the largest concentrations anywhere on this site, because the vials are ten to twenty times the size of an ordinary peptide vial. A 100 mg vial in 1 mL puts a milligram in a single unit, which means a half-unit reading error is half a milligram.
The circulating figures in syringe units
Figures stated on vendor and forum pages, recorded in this site's dosage chart on 2026-09-18, are 50 to 150 mg once daily by mouth and 2.5 to 5 mg once daily by injection. The oral figures cannot be converted at all — a capsule has no concentration — and the injectable figures convert as follows. They are reported because they circulate, not because a source stands behind them.
| Vial and water | 2.5 mg | 5 mg | 10 mg |
|---|---|---|---|
| 50 mg in 1 mL | 5 units | 10 units | 20 units |
| 50 mg in 2 mL | 10 units | 20 units | 40 units |
| 50 mg in 3 mL | 15 units | 30 units | 60 units |
| 100 mg in 1 mL | 2.5 units | 5 units | 10 units |
| 100 mg in 2 mL | 5 units | 10 units | 20 units |
| 100 mg in 3 mL | 7.5 units | 15 units | 30 units |
A 50 mg vial holds ten to twenty of the circulating injectable amounts; a 100 mg vial twice that. The oral and injectable figures sit an order of magnitude apart — 50 to 150 mg swallowed against 2.5 to 5 mg injected — and no source opened for this page reconciles them or reports a bioavailability figure that would.
What the mouse figures carry with them
The 5 and 10 mg/kg figures describe mice of a stated age, injured in a stated way, treated for one or three weeks, with muscle regeneration as the outcome. The obesity work describes mice on a high-fat diet with body weight and adipose mass as outcomes. Neither describes a route of administration in its abstract, neither reports a human pharmacokinetic profile, and there is no human safety data of any kind — no maximum tolerated dose, no adverse-event record, no drug-interaction study. The body-surface-area convention exists and gives about 28 and 57 mg for a 70 kg adult from those two figures, and the paper that sets the convention out states in its own abstract that animal doses should not be extrapolated this way and that the method is for planning early trials. A number produced by that arithmetic is a number for designing a study, which nobody has yet run.
What this page does not do
It does not state an amount of 5-Amino-1MQ to use, by any route, or a frequency, or a course. It converts stated figures into concentrations and syringe units exactly, and it states which figures came from an animal experiment, which from a chemical database and which from pages with no source at all. The compound's mechanism and evidence file are covered in Medibact's 5-Amino-1MQ guide; Peptifact's 5-Amino-1MQ dosage page reads the same literature from the journalism side. Decisions about administering anything to a person belong with a clinician.
Sources and dates
Opened 2026-09-19: PubMed through the NCBI E-utilities for 5-amino-1MQ and 5-amino-1-methylquinolinium in title or abstract (three records, PMIDs 39067875, 35013352 and 33645410, abstracts read) and for the NNMT-inhibitor work of the same laboratory (PMIDs 30753815 and 29155147, abstracts read); the ClinicalTrials.gov v2 API for 5-Amino-1MQ as an intervention and for the term NNMT inhibitor (no studies in either); the DailyMed SPL search API for 5-amino-1mq (zero records); PubChem compound records 950107 and 66522933 for the cation and iodide formulas and masses; Reagan-Shaw, Nihal and Ahmad, "Dose translation from animal to human studies revisited", FASEB J 2008 (PMID 17942826); MedlinePlus, "Giving an insulin injection" (reviewed 2024-07-21). The circulating figures are as recorded in this site's dosage chart on 2026-09-18. Corrections go to the contact page.