5-Amino-1MQ Reconstitution: The Salt Weight Problem

A 5-Amino-1MQ vial is usually the iodide salt, which is 44% heavier than the active cation. What that does to the concentration, and the water per vial.

Medibact Guides · Published 2026-09-21

Illustration: A digital scale with an empty glass vial and a spatula on a white surface.
Illustration

5-Amino-1MQ is the odd entry in this set. It is not a peptide, its vials are ten to twenty times larger than the peptide vials around it, and it is handled in milligrams rather than micrograms. All of that makes the arithmetic easier, not harder. What makes it genuinely different is a labelling question that most compounds here never raise: the substance is normally supplied as an iodide salt, and the salt is nearly twice the weight of the active part it carries. This page works through the water, the concentration and the units, and then works through what the salt does to all three. It reports and does not recommend.

The 5-Amino-1MQ calculator runs the same sums for any vial and volume, the sourced dose figures and their provenance are on the 5-Amino-1MQ dosage page, and every compound's arithmetic is indexed on the reconstitution hub.

Water per vial and the concentration it gives

One U-100 unit is a hundredth of a millilitre. The concentrations here are stated in milligrams per millilitre rather than micrograms, because at this scale micrograms produce unreadable numbers.

Vial Water Concentration One unit holds
50 mg 1 mL 50 mg/mL 0.5 mg
50 mg 2 mL 25 mg/mL 0.25 mg
50 mg 3 mL 16.7 mg/mL 0.167 mg
100 mg 1 mL 100 mg/mL 1 mg
100 mg 2 mL 50 mg/mL 0.5 mg
100 mg 3 mL 33.3 mg/mL 0.333 mg

A 100 mg vial in 1 mL is a 10% solution, and 50 mg in 1 mL is 5%. For comparison, a 10 mg peptide vial in 2 mL is 0.5%. Whether a given amount of this compound will actually dissolve at those concentrations is a property of the specific material and its salt form, and is not something arithmetic can answer; the table states what the concentration would be if it does.

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What the draws read as

Amount 50 mg in 1 mL 50 mg in 2 mL 50 mg in 3 mL 100 mg in 1 mL 100 mg in 2 mL
1 mg 2 units 4 units 6 units 1 unit 2 units
2.5 mg 5 units 10 units 15 units 2.5 units 5 units
5 mg 10 units 20 units 30 units 5 units 10 units
10 mg 20 units 40 units 60 units 10 units 20 units

These are comfortable readings across the whole table, which is the one respect in which this compound is easier than the microgram-scale peptides on neighbouring pages: nothing here lands at half a unit.

The salt, and why it is the real question

The published work uses the iodide salt. The 2024 bladder-cancer paper names it in full — "5-Amino-1-methylquinolinium iodide" — and PubChem lists it as a separate entry from the cation:

Species Formula Molecular weight PubChem CID
Active cation C10H11N2+ 159.21 950107
Iodide salt C10H11IN2 286.11 66522933

The cation is 159.21 of the salt's 286.11, which is 55.6%. So:

If the vial is labelled 50 mg vial contains 100 mg vial contains
by cation (free base) weight 50 mg of active 100 mg of active
by iodide salt weight 27.8 mg of active 55.6 mg of active

The difference is a factor of 1.8. To put that in context, the entire span of water volumes on this page — 1 mL to 3 mL — changes a reading by a factor of three, and people take care over that choice. The salt question changes the underlying amount by nearly two, and it is invisible: it lives in a labelling convention rather than in anything a person doing the arithmetic can see or measure.

No vendor label this site could check states which convention it uses. That is the honest end of this section. The arithmetic can show what the two possibilities are; it cannot say which one applies to any particular vial, and nothing on this page should be read as resolving it.

How many amounts a vial holds

Set by the milligrams in the vial, unchanged by the water:

Amount 50 mg vial 100 mg vial
2.5 mg 20 40
5 mg 10 20
10 mg 5 10

If the vial is labelled by salt weight, the counts above are still correct as counts of draws — but each draw carries 55.6% as much of the active cation.

What is not established

Almost everything about this compound's use in people. There is no human study of any size: three preclinical records exist under the full chemical name, covering mice on a low-fat diet, mouse bladder-cancer models and HeLa cells, and nothing else. ClinicalTrials.gov returned zero registrations and DailyMed zero labels on 2026-09-21, both checked in the same session as searches that returned results.

One detail of that census is worth stating on its own, because it is the sort of thing that produces a wrong number quietly. A search for the name the vial is sold by — 5-Amino-1MQ — returns nothing at all. The literature is there, but only under the full chemical name. A page reporting that this compound has no published research would be wrong; a page reporting that it has no human research is right. The difference is one search term.

Finally, the compound is widely sold as an oral capsule in the same 50 mg and 100 mg strengths as the vial. An oral capsule and an injected solution are not interchangeable amounts, and the figures circulating for the two routes differ by roughly twentyfold — 50 to 150 mg orally against 2.5 to 5 mg injected, per this site's chart. Neither figure has a published source that this site could find.

The mechanism and the evidence file are covered in Medibact's 5-Amino-1MQ guide. For a compound whose published amounts are per kilogram rather than fixed, the Melanotan II reconstitution page works that case through, and the all-compounds chart sets every compound's figures side by side.

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Frequently asked questions

How much bacteriostatic water goes into a 50 mg 5-Amino-1MQ vial?

No label sets it, because no vial of this compound has one — DailyMed held no record on 2026-09-21. The calculator's presets are 1, 2 and 3 mL, giving 50, 25 and 16.7 mg/mL from a 50 mg vial and 100, 50 and 33.3 mg/mL from a 100 mg vial. These are far higher concentrations than anything else on this site, where a typical vial produces single-digit milligrams per millilitre, and that is a consequence of the vial being ten to twenty times larger than a peptide vial.

Does the iodide salt change the amount in the vial?

If the vial is labelled by salt weight, yes, by a factor of about 1.8. The iodide salt weighs 286.11 and the active cation it carries weighs 159.21, so 55.6% of the salt's mass is the active portion. Fifty milligrams of the salt therefore contains 27.8 mg of the cation, and reaching 50 mg of the cation would need 89.9 mg of the salt. Whether any given vial is labelled by salt or free-base weight is not something this site can determine, and the two conventions differ by nearly a factor of two — which is larger than most of the differences anyone would try to manage by adjusting a water volume.

How many units is 5 mg of 5-Amino-1MQ?

From a 50 mg vial: 10 units in 1 mL, 20 in 2 mL and 30 in 3 mL. From a 100 mg vial: 5 units in 1 mL, 10 in 2 mL and 15 in 3 mL. If the vial is labelled by iodide salt weight, the same draws carry 55.6% as much of the active cation — so 10 units from a 50 mg salt vial in 1 mL is 2.78 mg of cation rather than 5 mg.

Is 5-Amino-1MQ a peptide?

No. It is a small quaternary ammonium compound with a molecular weight of 159.21 — a single ring system, not a chain of amino acids — and it inhibits the enzyme nicotinamide N-methyltransferase. It sits on this site because it is sold as a lyophilised vial that is reconstituted and drawn on the same syringes, and the arithmetic of concentration and units is identical whatever the molecule is. Its chemistry does differ in one way that matters: a small molecule sold as a salt raises a labelling question that a peptide sold as an acetate rarely does at this magnitude.

Are there any human studies of 5-Amino-1MQ?

None found. PubMed holds three records under the full chemical name — all preclinical, in mice and in cell lines — and none under the abbreviated name the vial is sold by. ClinicalTrials.gov returned zero registrations and DailyMed zero labels on 2026-09-21. The three papers that exist are real research, but they report an enzyme inhibitor given to animals and cells, and none of them establishes an amount for a person.

How many doses does a 5-Amino-1MQ vial hold?

At the 5 mg injectable figure that circulates, a 50 mg vial holds ten and a 100 mg vial twenty; at 2.5 mg, twenty and forty. If the vial is labelled by iodide salt weight, those counts are unchanged but each draw carries 55.6% as much active substance. The count follows from the milligrams in the vial and never from the water, which decides only how many units each draw reads.