Glutathione Reconstitution: Vials, 200 mg/mL and Units

How 200 mg to 2,000 mg glutathione vials convert to mg/mL and syringe volume, beside the labelled 150 mg/mL and the pharmacy 200 mg/mL presentations.

Medibact Guides · Published 2026-09-18

Illustration: A clear glass vial with pale blue liquid and a graduated syringe on a white lab bench. — Illustration

Glutathione is a tripeptide, glutamate, cysteine and glycine, and the principal antioxidant inside human cells. It reaches this site by a different route from most compounds here: it is sold as a lyophilized powder for injection in vials from 200 mg to 2,000 mg, the sizes the glutathione calculator carries, and also as a ready-made solution from compounding pharmacies. This page reports the water volumes the sources state, the concentrations they produce, and what the milligram amounts in circulation come to as syringe volumes. It reports and does not recommend. The figures and their provenance are on the glutathione dosage page; every compound's arithmetic is indexed on the reconstitution hub.

Two presentations, one arithmetic

Glutathione is unusual on this hub because a labelled, ready-made presentation exists alongside the powder, and the two are routinely confused.

The solution is what US compounding pharmacies dispense: 200 mg/mL in a 30 mL vial, preserved or preservative-free, for intravenous or intramuscular administration by a healthcare professional (Empower Pharmacy, opened 2026-09-18). Nothing is reconstituted; each millilitre is 200 mg, and the vial holds 6,000 mg.

The powder is what research vendors sell and what the one labelled product in this page's sources also is: TAD 600 mg/4 ml, an Italian powder-and-solvent product whose leaflet states 646 mg of sodium glutathione, equivalent to 600 mg of glutathione, reconstituted with 4 mL of water for injection to 150 mg/mL. Its 2,500 mg presentation takes 25 mL and reaches 100 mg/mL. A research vial's concentration is whatever the water makes it: 600 mg becomes 300, 200, 150 or 100 mg/mL at 2, 3, 4 or 6 mL.

A volume figure quoted for the pharmacy solution is therefore wrong for a powder unless the powder happens to have been made up to 200 mg/mL, which the vendor guide's 3 mL configuration does and the label's 4 mL does not.

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What the sources state

Source	What it states	Kind of source	Opened
DailyMed search, "glutathione"	57 records: homeopathic and dietary liquids and topical products; no injection	Regulator database	2026-09-18
TAD 600 mg/4 ml leaflet, AIFA, 2021-04-29	646 mg sodium glutathione = 600 mg glutathione; 4 mL water for injection; 150 mg/mL; IM or slow IV; 1.5 g/m² (about 2.5 g) by slow infusion for cisplatin-neuropathy prophylaxis, 600 mg IM or slow IV for long courses; solution stable 8 hours at room temperature, single use	Authorised product leaflet	2026-09-18
Sechi et al., Prog Neuropsychopharmacol Biol Psychiatry 1996	600 mg intravenously twice daily for 30 days, nine patients with early Parkinson's disease, open-label	Peer-reviewed pilot study	2026-09-18
Hauser et al., Movement Disorders 2009	1,400 mg intravenously three times a week for 4 weeks, 21 patients randomized to glutathione or placebo; no significant difference in rating-scale scores	Peer-reviewed randomized pilot trial	2026-09-18
Empower Pharmacy	200 mg/mL, 30 mL vial, preserved and preservative-free; IV or IM by a healthcare professional; "600 mg to 1,400 mg per session, administered two to three times per week" as clinical-study protocols	Compounding pharmacy	2026-09-18
FormBlends guide, updated 2026-09-03	600 mg lyophilized vial with 3 mL of bacteriostatic water, 200 mg/mL, or 6 mL, 100 mg/mL	Vendor guide	2026-09-18

The pharmacy's 600 to 1,400 mg figures are the two Parkinson's trials, both intravenous. The leaflet's figures are for a chemotherapy indication. No source opened states a subcutaneous figure from a study.

Water per vial and the concentration it gives

The table gives the water that produces the concentrations in circulation, 100, 150, 200 and 300 mg/mL, from each of the calculator's vial sizes. The calculator's standard 1, 2 and 3 mL columns are included where they fall in that range.

Vial	Water added	Concentration	Milligrams per U-100 unit
200 mg	1 mL	200 mg/mL	2 mg
200 mg	2 mL	100 mg/mL	1 mg
600 mg	2 mL	300 mg/mL	3 mg
600 mg	3 mL	200 mg/mL	2 mg
600 mg	4 mL (the label's solvent)	150 mg/mL	1.5 mg
600 mg	6 mL	100 mg/mL	1 mg
1,000 mg	5 mL	200 mg/mL	2 mg
1,000 mg	10 mL	100 mg/mL	1 mg
1,500 mg	7.5 mL	200 mg/mL	2 mg
2,000 mg	10 mL	200 mg/mL	2 mg
2,000 mg	20 mL	100 mg/mL	1 mg

A 2,000 mg vial in 10 mL and a 200 mg vial in 1 mL are the same solution. What the larger vial changes is how many draws it holds, not any single draw.

The stated amounts as syringe volumes

The amounts the sources state are 200 mg (the calculator's smallest vial, and the mass in 1 mL of the pharmacy solution), 600 mg (the label's lower dose and the 1996 trial's) and 1,400 mg (the 2009 trial's). A U-100 insulin syringe holds 1 mL, 100 units (MedlinePlus, "Giving an insulin injection", reviewed 2024-07-21), so almost every cell below is a draw for a larger syringe.

Concentration	200 mg	600 mg	1,400 mg
300 mg/mL (600 mg in 2 mL)	0.67 mL (67 units)	2 mL	4.67 mL
200 mg/mL (pharmacy solution; 600 mg in 3 mL)	1 mL (100 units)	3 mL	7 mL
150 mg/mL (the label's 600 mg in 4 mL)	1.33 mL	4 mL, the whole vial	9.33 mL
100 mg/mL (600 mg in 6 mL)	2 mL	6 mL	14 mL

Only two cells fit an insulin syringe. That is the practical fact this compound's arithmetic produces: the amounts in circulation are millilitre-scale, the 1,400 mg trial figure is an infusion volume, and the label's 600 mg presentation is designed to be given whole.

The mixing steps, as the label describes them

The TAD leaflet is the only label-grade description of reconstituting lyophilized glutathione this page could open, and its steps are the ones every lyophilized vial follows: the 4 mL of water is drawn from its ampoule with a syringe fitted with a suitable needle; the aluminium tab is removed and the vial's rubber stopper disinfected with an alcohol swab; the needle is inserted through the centre of the stopper and the stream of water directed against the glass wall of the vial; the vial is agitated gently to complete dissolution; and the solution, which the leaflet states must be clear and free of visible particles, is administered intramuscularly or by slow intravenous injection for one uninterrupted administration, with any residue discarded. The general procedure for any lyophilized vial, step by step, is on Medibact's how to reconstitute peptides page and is not repeated here.

Storage after mixing

The TAD leaflet states that the reconstituted solution is stable for 8 hours at room temperature and serves a single administration; what labels and manufacturers state about reconstituted vials more generally is on Medibact's how to store peptides page.

What this page does not do

It does not state an amount of glutathione to use, a route, a frequency or a course. The 600 mg and 1,400 mg figures are reported because a label, two trials and a pharmacy state them, and all of them are intravenous or intramuscular figures in patient groups that have nothing to do with a research vial; the 200 mg/mL and 150 mg/mL concentrations are reported because a pharmacy and a label state them. The arithmetic converts stated inputs exactly and says nothing about whether any input is appropriate. Medibact's Glutathione guide covers the compound; Peptifact's glutathione dosage page documents FDA's 2022 compounding review of it. Decisions about administering anything to a person belong with a clinician.

Sources and dates

Opened 2026-09-18: the DailyMed SPL search API for "glutathione" (57 records, all titles reviewed for a dosage form of injection); the AIFA patient leaflet for TAD 600 mg/4 ml and 2500 mg/25 ml (Biomedica Foscama, document dated 2021-04-29, sections 3, 5 and 6); PubMed through the NCBI E-utilities for the abstracts of PMID 8938817 (Sechi et al. 1996) and PMID 19230029 (Hauser et al. 2009) and the counts for glutathione[ti] AND intravenous[tiab] (238; 30 with the clinical-trial filter); the ClinicalTrials.gov v2 API for glutathione as an intervention (269 records); Empower Pharmacy's compounded glutathione injection page; the FormBlends glutathione injection guide (updated 2026-09-03); MedlinePlus, "Giving an insulin injection" (reviewed 2024-07-21). Corrections go to the contact page.

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Medibact Guides facts

Glutathione is a tripeptide of glutamate, cysteine and glycine. Its research vials are 200 mg, 600 mg, 1,000 mg, 1,500 mg and 2,000 mg, the sizes the calculator carries; a research peptide vial is 5 mg or 10 mg, so the concentrations and draws here are 20 to 200 times larger.
No FDA-approved glutathione injection exists: DailyMed's 57 records for 'glutathione' on 2026-09-18 are homeopathic and dietary liquids and topical products, none of them an injection.
A labelled lyophilized presentation exists in Italy: TAD 600 mg/4 ml (Biomedica Foscama; patient leaflet published by the medicines agency AIFA on 2021-04-29) contains 646 mg of sodium glutathione, equivalent to 600 mg of glutathione, is reconstituted with 4 mL of water for injection to 150 mg/mL for intramuscular or slow intravenous use, and its 2,500 mg/25 ml infusion presentation reconstitutes to 100 mg/mL.
That leaflet's posology is 1.5 g/m² (about 2.5 g) by slow intravenous infusion for prophylaxis of neuropathy from cisplatin chemotherapy, and 600 mg intramuscularly or by slow intravenous injection for longer courses; it states the reconstituted solution is stable for 8 hours at room temperature and serves a single administration.
Compounding pharmacies in the United States dispense glutathione as a ready-made 200 mg/mL solution in 30 mL vials, preserved or preservative-free, for intravenous or intramuscular administration by a healthcare professional; the pharmacy page opened on 2026-09-18 (Empower Pharmacy) cites clinical protocols of 600 to 1,400 mg per session, two to three times a week.
The two Parkinson's disease trials behind those figures gave 600 mg intravenously twice daily for 30 days to nine patients, open-label (Sechi et al., 1996), and 1,400 mg intravenously three times a week for four weeks to 21 randomized patients, with no significant difference from placebo on the rating scale (Hauser et al., Movement Disorders 2009).
A vendor guide updated 2026-09-03 works a 600 mg lyophilized vial at 3 mL of bacteriostatic water, 200 mg/mL, and at 6 mL, 100 mg/mL (FormBlends); the labelled product reaches 150 mg/mL at its supplied 4 mL.
At 200 mg/mL a 200 mg amount is 1 mL, the full barrel of a U-100 insulin syringe, and a 600 mg amount is 3 mL. The amounts in circulation for glutathione are millilitre-scale draws for a 3 mL or 5 mL syringe, not insulin-syringe units.
PubMed held 238 records with glutathione in the title and 'intravenous' in the title or abstract on 2026-09-18, 30 of them tagged as clinical trials; ClinicalTrials.gov held 269 records with glutathione as an intervention, most of them oral.

Frequently asked questions

How much water goes into a 600 mg vial of glutathione?

The one labelled lyophilized product supplies 4 mL of water for injection with each 600 mg vial, giving 150 mg/mL (TAD 600, Italian leaflet of 2021-04-29). A vendor guide opened on 2026-09-18 works the same vial at 3 mL of bacteriostatic water, 200 mg/mL, or 6 mL, 100 mg/mL. The calculator accepts any of them. The volume sets how many millilitres a stated amount occupies; it does not change the 600 mg in the vial.

How many units is 200 mg of glutathione on an insulin syringe?

At 200 mg/mL, exactly 100 units, which is the whole 1 mL barrel. At 150 mg/mL, the labelled concentration, 200 mg is 1.33 mL and does not fit an insulin syringe; at 100 mg/mL it is 2 mL. This is why glutathione pages describe draws in millilitres for a 3 mL or 5 mL syringe rather than in units: the amounts in circulation are hundreds of milligrams and the solutions are at most 200 to 300 mg/mL.

What is the difference between a 200 mg/mL vial and a lyophilized vial?

A pharmacy's 200 mg/mL product is already a solution: a 30 mL vial holds 6,000 mg and every millilitre is 200 mg regardless of anything done to it. A lyophilized vial is a powder whose concentration is set by the water added, so 600 mg becomes 300, 200, 150 or 100 mg/mL at 2, 3, 4 or 6 mL. A volume figure copied from one presentation to the other is wrong unless the concentrations happen to match.

Is there an approved glutathione injection?

Not in the United States: DailyMed holds no glutathione injection label, and the compounded 200 mg/mL products are prepared under pharmacy rules rather than approved. In Italy, TAD 600 mg/4 ml is an authorised powder-and-solvent product, indicated for prophylaxis of neuropathy from cisplatin chemotherapy, with an infusion presentation of 2,500 mg in 25 mL. Its leaflet is the only label-grade description of reconstituting lyophilized glutathione this page could open.

What doses did the intravenous glutathione trials use?

Sechi and colleagues gave 600 mg intravenously twice daily for 30 days to nine patients with early Parkinson's disease, open-label, in 1996. Hauser and colleagues randomized 21 patients to 1,400 mg intravenously or placebo three times a week for four weeks in 2009 and found no significant difference in rating-scale scores. The pharmacy page's 600 to 1,400 mg per session is those two trials. Both were intravenous, in a specific disease, and neither is a subcutaneous figure.

How is lyophilized glutathione reconstituted, according to the label?

The TAD leaflet describes drawing the 4 mL of water from its ampoule with a syringe, disinfecting the vial stopper, inserting the needle through its centre and directing the stream of water against the glass wall of the vial, agitating gently until dissolved, and using the solution only if clear and free of visible particles, for one administration. Medibact's reconstitution page carries the general procedure for any lyophilized vial; this page carries only the arithmetic.